The investigation into the efficacy of angiotensin receptor blocker against metabolic syndrome

血管紧张素受体阻滞剂抗代谢综合征的疗效研究

• 批准号: 20790401
• 负责人: TOBA Hiroe
• 金额: $ 2万
• 依托单位: Kyoto Pharmaceutical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790401/
• 关键词: 臨床薬理学; メタボリックシンドローム

We have demonstrated that telmisartan inhibited renal and aortic injury in the diabetic rat model and these beneficial effects were stronger than those of other angiotensin receptor blocker (ARB), which have exhibitied similar antihypertensive effects to those of telmisartan. In addition, we also showed that treatment with telmisartan suppressed inflammation in the H_2O_2-treated cultured vascular endothelial cells by PPARγ.

我们已经证明，替米沙坦可以抑制糖尿病大鼠模型中的肾和主动脉损伤，并且这些有益作用比其他血管紧张素受体阻滞剂（ARB）更强，后者表现出与替米沙坦相似的抗高血压作用。此外，我们还表明，替米沙坦治疗可通过 PPARγ 抑制经 H_2O_2 处理的培养血管内皮细胞的炎症。

项目成果

Spironolactone exhibits direct renoprotective effects and inhibits renal renin-angiotensin-aldosterone system in diabetic rats

• DOI: 10.1016/j.ejphar.2008.06.019
• 发表时间: 2008-07-28
• 期刊: EUROPEAN JOURNAL OF PHARMACOLOGY
• 影响因子: 5
• 作者: Taira, Masateru;Toba, Hiroe;Nakata, Tetsuo
• 通讯作者: Nakata, Tetsuo

Nakata T Spironolactone exhibits direct renoprotective effects and inhibits renal renin-angiotensin-aldosterone system in diabetic rats.

Nakata T Spironolactone 在糖尿病大鼠中表现出直接的肾脏保护作用并抑制肾脏肾素-血管紧张素-醛固酮系统。

• 发表时间: 2008
• 期刊: European Journal of Pharmacology 589(1-3)
• 作者: Taira M;Toba H;Murakami M;Iga I;Serizawa R;Murata S;Kobara M
• 通讯作者: Kobara M

Erythropoietin attenuates diabetic nephropathy beyond hematopoiesis in streptozotocin-induced diabetic rats

促红细胞生成素在链脲佐菌素诱导的糖尿病大鼠中除了造血作用之外还可以减轻糖尿病肾病

• 发表时间: 2008
• 作者: Hiiroe T;et.al.
• 通讯作者: et.al.

Spironolactone attenuated renal and vascular dysfunction via antioxidant properties and inhibited renal expression of ACE and CYP11B2 in deoxycorticosterone-salt rats

螺内酯通过抗氧化特性减轻肾和血管功能障碍，并抑制脱氧皮质酮盐大鼠肾中 ACE 和 CYP11B2 的表达

• 发表时间: 2008
• 作者: Hiiroe T;et.al.
• 通讯作者: et.al.

Oral L-histidine exerts antihypertensive effects via central histamine H3 receptors and decreases nitric oxide content in the rostral ventrolateral medulla in spontaneously hypertensive rats

口服 L-组氨酸通过中枢组胺 H3 受体发挥抗高血压作用，并降低自发性高血压大鼠延髓头端腹外侧区的一氧化氮含量

• 发表时间: 2010
• 期刊: Clininal and Experimental Pharmacology and Physiology 37(1)
• 作者: Toba H;Nakamori A;Tanaka Y;Yukiya R;Tatsuoka K;Narutaki M;Tokitaka M;Hariu H;Kobara M;Nakata T.
• 通讯作者: Nakata T.