Effects of oral exposure to pesticide residues in allergic diseases during early childhood.

幼儿时期口服农药残留对过敏性疾病的影响。

• 批准号: 20790432
• 负责人: YANAGISAWA Rie
• 金额: $ 2.66万
• 依托单位: National Institute for Environmental Studies
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790432/
• 关键词: 食品衛生; アレルギー・ぜんそく; マイクロアレイ; 環境; 免疫学; 衛生

Pesticide residues, ones of environmental pollutants, may increase the potency of allergens and thereby play a role in the onset and progression of allergic diseases. We determined whether oral exposure to pesticides in early childhood affect allergic diseases including atopic dermatitis and allergic airway inflammation in murine model. Exposure to pesticides did not show significant enhancing effects in atopic dermatitis-like skin lesions either male or female mice. On the other hand, γ- benzene hexachloride (BHC) aggravated allergen-related airway inflammation in female mice, but not male mice. Taken together, oral exposure to pesticides in early childhood can show various effects in the type of disorders and/or sex differences.

农药残留是环境污染物之一，可增加过敏原的效力，从而在过敏性疾病的发生和发展中发挥作用。我们在小鼠模型中确定儿童早期口服农药是否会影响过敏性疾病，包括特应性皮炎和过敏性气道炎症。暴露于农药没有表现出显着的增强效应，在特应性皮炎样皮肤病变，无论是雄性或雌性小鼠。另一方面，γ-苯六六六（BHC）加重了雌性小鼠过敏原相关的气道炎症，但对雄性小鼠没有影响。综上所述，幼儿期口服农药暴露可对疾病类型和/或性别差异产生各种影响。