The effect of chemical chaperone on myocardial ischemia-reperfusion injury and infarction in mice

化学伴侣对小鼠心肌缺血再灌注损伤和梗死的影响

• 批准号: 20790521
• 负责人: OKAJIMA Masaki
• 金额: $ 1.58万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790521/
• 关键词: ERストレス; 虚血再灌流; 心筋梗塞; シャペロン; シヤペロン

We assessed the hypothesis that 4-PBA (chemical chaperone) reduces endoplasmic reticulum stress (ER stress) mediated apoptosis and protects against myocardial ischemia-reperfusion injury or myocardial infarction in mice. In result, 4-PBA reduced ER stress mediated apoptosis, decreased infarct size, maintained cardiac function and improved survival ratio in mice with ischemia-reperfusion. On the other hand, 4-PBA inhibited fibrosis and induced cardiac rupture in mice with myocardial infarction.

我们评估的假设，4-PBA（化学伴侣）减少内质网应激（ER应激）介导的细胞凋亡，并保护小鼠心肌缺血再灌注损伤或心肌梗死。结果表明，4-PBA可减少ER应激介导的细胞凋亡，缩小心肌梗死面积，维持心功能，提高小鼠存活率。另一方面，4-PBA可抑制心肌梗死小鼠的纤维化并诱导心脏破裂。

项目成果

Sodium 4-phenylbutylate protects against myocardial ischemia-reperfusion injury by reducing unfolded protein response-mediated apoptosis in mice.

4-苯基丁酸钠通过减少小鼠中未折叠蛋白反应介导的细胞凋亡来防止心肌缺血再灌注损伤。

• 发表时间: 2010
• 作者: Okajima;M.;Takamura;M.;Usui;S.;Taniguchi;T.;Kanako;S.
• 通讯作者: S.

Sodium 4-phenylbutylate reduces myocardial ischemia-reperfusion injury in mice.

4-苯基丁酸钠可减轻小鼠心肌缺血再灌注损伤。

• 发表时间: 2008
• 作者: Okajima;M.;Takamura;M.;Kaneko S.
• 通讯作者: Kaneko S.