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To discover a novel therapy for preventing atherosclerosis by modulating the interaction between endothelial cell s- monocytes

To discover a novel therapy for preventing atherosclerosis by modulating the interaction between endothelial cell s- monocytes
发现一种通过调节内皮细胞-单核细胞之间的相互作用来预防动脉粥样硬化的新疗法
批准号:
20790530
负责人:
YASUDA Tomoyuki
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009

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中文摘要
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英文摘要
Our aim is to analyze the effect of ESAM on the progression of atherosclerosis. We generated ESAM / apoE double knockout mice and analyzed atherosclerosis lesion size. We also generated ESAM expression reduced endothelial cell by SiRNA method. We found that ESAM inhibition reduced the invasion of monocytes through endothelial cells and ESAM deficiency reduced atherosclerosis in apoE knockout mice. ESAM inhibition might be a novel therapy for preventing atherosclerosis.
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会议论文
Pitavastatin decreases expression of endothelial lipase both in vitro and in vivo.
匹伐他汀在体外和体内均可降低内皮脂肪酶的表达。
DOI: --
发表时间: 2010
期刊: Cardiovasc Res 87(2)
影响因子: --
作者: [Kojima Y, Ishida T, Sun L, Yasuda T, Toh T, Rikitake Y, Fukuda A, Kume N, Koshiyama H, Taniguchi A, Hirata K]
通讯作者: Hirata K
Targetd inactivation of receptor for advanced glycation products reduced oxidative LDL-induced inflammation and atherosclerosis in non-diabetic LDL receptor-/-mice.
晚期糖化产物受体的靶向失活可减少非糖尿病 LDL 受体-/-小鼠中氧化 LDL 诱导的炎症和动脉粥样硬化。
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Sun L, Ishida T, Kuriyama M, Yasuda T, Hara T, Hirata K, Hayashi Y.]
通讯作者: Hayashi Y.
Effect of pitavastatin on serum concentrations of endothelial lipase and high-density lipoprotein cholesterol in humans
匹伐他汀对人血清内皮脂肪酶和高密度脂蛋白胆固醇浓度的影响
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Sun Li, Tatsuro Ishida, Yoko Kojima, Tomoyuki Yasuda, Akira Fukuda, Fumie Kureha, Ken-ichi Hirata]
通讯作者: Ken-ichi Hirata
Inhibition of endothelial lipase can raise anti-atherogenic HDL particles.
抑制内皮脂肪酶可以提高抗动脉粥样硬化的高密度脂蛋白颗粒。
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [石田達郎, 安田知行, 福田亨, 平田健一]
通讯作者: 平田健一
20
    To explore the biomarkers which determine the quality of high density lipopotein
    • 批准号:
      23790853
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.66万
    • 财政年份:
      2011
    • 负责人:
      YASUDA Tomoyuki
    • 依托单位:
    Analytic investigations of the application of program evaluation methods in psycho-educational/social work practices
    • 批准号:
      21730567
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $1.58万
    • 财政年份:
      2009
    • 负责人:
      YASUDA Tomoyuki
    • 依托单位:
    海外基金