The role of HMGB1 in the development and expansion of aortic aneurysm

HMGB1在主动脉瘤发生发展中的作用

• 批准号: 20790548
• 负责人: KOHNO Takashi
• 金额: $ 2.66万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790548/
• 关键词: 分子血管病態学; 大動脈瘤; 炎症性サイトカイン; 自然免疫

Experimental AAA model was induced by periaortic application of calcium chloride in male mice. The protein expression of HMGB1 was increased in the AAA, compared with those in control mice. We administered neutralizing anti-HMGB1 antibody (AAA/antiH) or control antibody (AAA/C) to AAA mice subcutaneously. HMGB1 blockade suppressed experimental AAA formation. The expression of proinflammatory cytokines, metalloproteinase-9 activity, and the number of macrophages in the aorta were reduced in AAA/antiH compared with AAA/C.

实验性AAA模型通过在雄性小鼠的主动脉周围应用氯化钙来诱导。AAA组HMGB 1蛋白表达明显高于对照组。我们给AAA小鼠皮下注射中和性抗HMGB 1抗体（AAA/antiH）或对照抗体（AAA/C）。HMGB 1阻断抑制实验性AAA形成。与AAA/C相比，AAA/antiH中促炎细胞因子的表达、金属蛋白酶-9活性和主动脉中巨噬细胞的数量减少。

项目成果

High mobility group box 1 protein expression is associated with expansion and rupture of human abdominal aortic aneurysm

高迁移率族蛋白1蛋白表达与人腹主动脉瘤扩张和破裂相关

• 发表时间: 2009
• 作者: Kohno T;Anzai T;Kaneko H;Shimizu H;Shimoda M;Miyasho T;Okamoto M;Yokota H;Yamada S;Yoshikawa T;Okada Y;Ishizaka A;Yozu R;Ogawa S.
• 通讯作者: Ogawa S.

Increased High-Mobility Group Box1 Expression at Ruptured Plaque was Associated with Microvascular Damage after Reperfusion in Patients with Myocardial Infarction

破裂斑块处高迁移率族 Box1 表达增加与心肌梗死患者再灌注后微血管损伤相关

• 发表时间: 2010
• 作者: Kohno T;Anzai T;Ohki T;Itabashi Y;Yoshizawa A;Yamada S;Yoshikawa T;Ogawa S.
• 通讯作者: Ogawa S.

ST上昇型心筋梗塞における血清HMGB1値上昇の臨床的意義

ST段抬高型心肌梗死血清HMGB1水平升高的临床意义

• 发表时间: 2009
• 作者: 河野隆志;安斉俊久;安西淳;金子英弘;眞野恵範;内藤広太郎;前川裕一郎;宮庄拓;山田晋吾;横田博;吉川勉;石坂彰敏;小川聡
• 通讯作者: 小川聡

Serum high mobility group box 1 protein elevation is associated with acute respiratory distress syndrome following thoracic aortic aneurysm repair

血清高迁移率族蛋白1蛋白升高与胸主动脉瘤修复术后急性呼吸窘迫综合征相关

• 发表时间: 2009
• 作者: Kohno T;Kohno T;Anzai T;Shimizu H;Kaneko H;Jo Y;Yamada S;Yoshikawa T;Ishizaka A;Yozu R;Ogawa S.
• 通讯作者: Ogawa S.

High mobility group box 1 protein expression is associated with expansion and runture of human abdominal aortic aneurysm.

高迁移率族蛋白1的表达与人腹主动脉瘤的扩张和破裂有关。

• 发表时间: 2009
• 作者: Kohno T;Anzai T;Kaneko H;Shimizu H;Shimoda M;Miyasho T;Okamoto M;Yokota H;Yamada S;Yoshikawa T;Okada Y;Ishizaka A;Yozu R;Ogawa S.;Ueno H;Kohno.T
• 通讯作者: Kohno.T