Lineage-specific survival signal of lung adenocarcinoma on the lung development master regulator
Lineage-specific survival signal of lung adenocarcinoma on the lung development master regulator
批准号:
20790566
负责人:
YAMAGUCHI Tomoya
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
除了正常肺细胞谱系的发育和维持外,TTF-1的持续表达在肺腺癌的存活中起着至关重要的作用。在本研究中,我们发现DOT-1是ttf -1调控的基因,我们发现表达DOT-1的肺腺癌高度依赖其表达来维持细胞存活。
英文摘要
Sustained TTF-1 expression plays a crucial role in the survival of lung adenocarcinoma, in addition to the development and maintenance of cell lineages in normal lung. In this study, we identified DOT-1, as a TTF-1-regulated gene, and we showed lung adenocarcinoma expressing DOT-1 are highly dependent on its expression for cell survival.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
細胞増殖阻害剤
细胞生长抑制剂
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[]
通讯作者:
Construction of scientific foundation for drug delivery technology using caveolae vesicles
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批准号:19K22565
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项目类别:Grant-in-Aid for Challenging Research (Exploratory)
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资助金额:$4.16万
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财政年份:2019
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负责人:YAMAGUCHI Tomoya
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依托单位:
Role of ROR1-mediated caveolae function in cell membrane organization and dynamics
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批准号:18H02683
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.07万
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财政年份:2018
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负责人:YAMAGUCHI Tomoya
-
依托单位:
Lineage-specific survival signal of lung adenocarcinoma on the lung
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批准号:22790753
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.5万
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财政年份:2010
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负责人:YAMAGUCHI Tomoya
-
依托单位: