The molecular mechanism and physiological significance of thyroid hormone non-genomic action

甲状腺激素非基因组作用的分子机制及生理意义

• 批准号: 20790658
• 负责人: SOU Kasumi
• 金额: $ 2.75万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790658/
• 关键词: 甲状腺ホルモン; ノンゲノミック作用PI3K→Akt; ノンゲノミック作用; シグナル伝達; 甲状腺ホルモン(T3); nongenomic作用; シグナリング伝達

We have reported previously that thyroid hormone (T3) stimulates the PI3K/Akt pathway through thyroid hormone receptor (TR).It is a non-genomic action since the novel protein synthesis is not involved in. In the present study we demonstrated that T3 promotes the complex formation of TR/Src/p85, which induces the phosphorylation of Src and p85 sequentially and results in the activation of PI3K→Akt. This novel T3 action plays important role in neuronal cell survival.

我们以前已经报道，甲状腺激素(T3)通过甲状腺激素受体(TR)刺激PI3K/Akt通路，这是一种非基因组作用，因为新的蛋白质合成不参与。在本研究中，我们证明了T3促进了tr/src/p85复合体的形成，进而诱导src和p85的磷酸化，导致PI3K→Akt的激活。这种新的T3作用在神经细胞的存活中起着重要作用。

项目成果

Thyroid hormone non-genomically suppresses Src thereby stimulating osteocalcin expression in primary mouse calvarial osteoblasts

• DOI: 10.1016/j.bbrc.2009.06.131
• 发表时间: 2009-09-11
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Asai, Shuji;Cao, Xia;Kambe, Fukushi
• 通讯作者: Kambe, Fukushi

Thyroid-hormone-dependent activation of the phosphoinositide 3-kinase/Akt cascade requires Src and enhances neuronal survival

• DOI: 10.1042/bj20090643
• 发表时间: 2009-12-01
• 期刊: BIOCHEMICAL JOURNAL
• 影响因子: 4.1
• 作者: Cao, Xia;Kambe, Fukushi;Seo, Hisao
• 通讯作者: Seo, Hisao

3beta-Hydroxysteroid-delta24 reductase is a hydrogen peroxide scavenger, protecting cells from oxidative stress-induced apoptosis.

3beta-Hydroxysteroid-delta24 还原酶是一种过氧化氢清除剂，可保护细胞免受氧化应激诱导的细胞凋亡。

• 发表时间: 2008
• 期刊: Endocrinology 149
• 作者: Lu X.;Kambe F.;Cao X.;Kozaki Y.;Kaji T.;Ishii T.;Seo H.
• 通讯作者: Seo H.

Thyroid hormone activates adenosine 5'-monophosphate-activated protein kina-se, via intracellular calcium mobilization and activ-ation of calcium/calmodulin-dependent protein kinase beta.

甲状腺激素通过细胞内钙动员和钙/钙调蛋白依赖性蛋白激酶β的激活来激活腺苷5-单磷酸激活蛋白激酶。

• 发表时间: 2008
• 期刊: Mol Endocrinol. 22(4)
• 作者: Yamauchi M;Kambe F;Cao X;Lu X;Kozaki Y;Oiso Y;Seo H.
• 通讯作者: Seo H.

Prostaglandin E2 negatively regulates AMP-activated protein kinase via protein kinase A signaling pathway

• DOI: 10.1016/j.prostaglandins.2008.09.002
• 发表时间: 2009-01-01
• 期刊: PROSTAGLANDINS & OTHER LIPID MEDIATORS
• 影响因子: 2.9
• 作者: Funahashi, Koji;Cao, Xia;Kambe, Fukushi
• 通讯作者: Kambe, Fukushi