In vivo characterization of B cells with lymphoma-specific translocat in mice and their potential roles in lymphoma development.

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To clarify how the BCL2/IGH translocation contributes to the development of lymphoma of germinal center B-cell origin, we used chimeric mouse models to examine the biological features of BCL2-overexpressing B cells. These cells showed a cell-autonomous differentiation preference for follicular B cells, and they have reduced responsiveness to terminal differentiation stimulation. We hypothesize that B cells that have undergone BCL2/IGH translocation might possibly be forced to localize in follicles, and accumulate genetic abnormalities by being subjected to recurrent stimulation.