Clinical research for disease mechanisms associated with TFL gene dysfunction in malignant lymphoid tumors

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We recently identified a novel gene with a similar CCCH-type zinc finger domain as a possible tumor suppressor gene that is involved in a cryptic breakpoint translocation found in human transformed follicular lymphoma. To clarify clinical significance for the gene, we analyzed the gene defect of 84 lymphoma patients. Eleven patients (15.3%) lose at least one allele. TFL protein inhibited cell growth and provoked apoptosis. As for its subcellular localization, it localized in the cytoplasmic granules called P-bodies. The inhibitory activity of TFL for lymphocyte proliferation highlights the potential utility of TFL as therapeutic targets for leukemia and/or lymphoma.