The maintenance mechanism of hematopoietic microenvironment bytranscription factor GATA-2

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GATA-2 is a transcription factor indispensable for hematopoiesis by regulating the proliferation and maturation of hematopoietic stem cells (HSC).We analyzed the function of GATA-2 in mesenchymal stem cells(MSC), and revealed that GATA-2 is activated in MSC and regulates the proliferation and maturation of MSC. Because hematopoietic microenvironment is formed by cells derived from MSC, it is suggested that GATA-2 is essential for not only HSC but also hematopoietic microenvironment by maintaining immaturity of MSC.