Cancer stem cell theory in thyroid carcinogenesis
Cancer stem cell theory in thyroid carcinogenesis
批准号:
20790662
负责人:
MITSUTAKE Norisato
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
我们已经成功地开发了一种新的培养系统,从人类正常甲状腺组织中分离干细胞。这些细胞不仅具有向甲状腺滤泡细胞分化的潜力,而且还具有向神经元细胞和脂肪细胞分化的潜力。分离的细胞可能直接从甲状腺滤泡细胞中重编程,这种重编程可能参与癌变过程中产生癌症干细胞。
英文摘要
We have successfully developed a novel culture system to isolate stem-like cells from human normal thyroid tissues. These cells had differentiation potentials not only into thyroid follicular cells but also into neuron or adipocytes. The isolated cells may be directly reprogrammed from thyroid follicular cells, and this reprogramming might be involved in generating cancer stem cells during carcinogenesis.
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甲状腺癌における癌遺伝子の役割と分子標的治療
癌基因和分子靶向治疗在甲状腺癌中的作用
DOI:
--
发表时间:
2009
期刊:
日本内科学会雑誌 98
影响因子:
--
作者:
[光武範吏, 山下俊一]
通讯作者:
山下俊一
DOI:
10.1677/erc-08-0336
发表时间:
2009-06-01
期刊:
ENDOCRINE-RELATED CANCER
影响因子:
3.9
作者:
[Akulevich, Natallia M., Saenko, Vladimir A., Yamashita, Shunichi]
通讯作者:
Yamashita, Shunichi
Mutational and clinicopathological analysis of papillary thyroid carcinoma in Serbian patients.
塞尔维亚甲状腺乳头状癌的突变和临床病理分析。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Matsuse M, et al., スタノエビッチボバン, Tatiana Rogounovitch, Natallia Akulevich, Boban Stanojevic]
通讯作者:
Boban Stanojevic
Mutational and clinico-pathological analysis of papillary thyroid carcinoma in Serbian patients Asia and Oceania
亚洲和大洋洲塞尔维亚患者甲状腺乳头状癌的突变和临床病理分析
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Rybaltowski M, Mogami H, Suzuki Y, Ihara H, Banno F, Miyata T, Urano T, Stanojevic B]
通讯作者:
Stanojevic B
Molecular and clinico-pathological analysis of pediatric thyroid cancers in Belarus
白俄罗斯儿童甲状腺癌的分子和临床病理学分析
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Abrosimov A, et. al., Tatiana Rogounovitch]
通讯作者:
Tatiana Rogounovitch
共 27 条
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Molecular epidemiological study of radiation-free pediatric and adolescent thyroid cancers around the Chernobyl area.
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批准号:16H05832
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财政年份:2016
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The molecular epidemiological study of DNA repair-related genes in post-Chernobyl radiation-induced thyroid cancers
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财政年份:2014
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负责人:MITSUTAKE Norisato
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依托单位:
Identification and functional analysis of novel markers for thyroid cancer stem cells
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项目类别:Grant-in-Aid for Scientific Research (C)
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财政年份:2011
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负责人:MITSUTAKE Norisato
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依托单位:
海外基金