Diagnostic usefulness of salivary steroid hormone measurement by LC-MS/MS in girls with PCOS

LC-MS/MS 测量唾液类固醇激素对 PCOS 女孩的诊断价值

• 批准号: 20790745
• 负责人: AMANO Naoko
• 金额: $ 1.66万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790745/
• 关键词: 小児内分泌学; 肥満; 思春期; ステロイドホルモン; PCOS; ステロイド分析

I measured salivary free steroid hormones by liquid chromatography-tandem mass spectrometry (LC-MS/MS), and compared the steroid hormone levels of obesity girls to non-obesity girls. The levels of DHEA, androstenedione and testosterone in obesity girls were significantly higher than those in non-obesity girls. I think that the secretions of those androgens are increased in obesity girls as well as adult women with polycystic ovary syndrome.

用LC-MS/MS法测定唾液中游离类固醇激素，并比较肥胖女孩和非肥胖女孩的类固醇激素水平。肥胖女孩的DHEA、雄烯二酮和睾酮水平显著高于非肥胖女孩。我认为，肥胖女孩和患有多囊卵巢综合征的成年女性的雄激素分泌都会增加。

项目成果

肥満思春期女児の唾液中遊離型AndrostenedioneとTestosteroneは高値である-LC-MS/MS法による検討-

肥胖少女唾液中游离雄烯二酮和睾酮的含量较高 - 使用 LC-MS/MS 方法进行的研究 -

• 发表时间: 2009
• 作者: 戸川寛子;中西浩一;佐古まゆみ;尾鼻美奈;島友子;宮嶋正康;西井一宏;長尾枝澄香;高橋久英;吉川徳茂;天野直子
• 通讯作者: 天野直子