Role of Angiotensin II in coronary artery lesion of Kawasaki disease

细胞外基质如干扰素-γ、肿瘤坏死因子-α、白介素6、基质金属蛋白酶等被认为参与了川崎病患者的冠状动脉病变。ARB在CAL中的潜在作用机制尚不清楚。探讨ARB对干酪乳杆菌细胞壁提取物(LCWE)诱导的川崎病模型小鼠冠状动脉炎症的预防作用。通过ARB治疗，可抑制对LCWE的炎症反应。更有趣的是，接受ARB治疗的小鼠与注射LCWE后的小鼠相比，局部冠状动脉中MMP2、MMP9、IL6mRNA的表达显著降低。因此，ARB有望成为川崎病患者预防CAL的一种新的治疗药物。

Extracellular matrix(ECD) such as INF-γ,TNF-α,IL-6,MMPs are thought to be involved in coronary artery lesions (CAL) in patients with Kawasaki disease (KD). The mechanisms underlying effects of ARB in CAL are not known. We discussed whether ARB could prevent Lactobacillus casei cell wall extract (LCWE)-induced coronary arteritis in murine model of KD. Inflammations in response to LCWE, are suppressed by ARB treatment. More interestingly, MMP-2, MMP-9, IL-6 mRNA expression at local coronary artery significantly decreased in mice treated with ARB compared with mice post-LCWE injection. Thus, this result suggests that ARB is expected to be a new therapeutic agent for preventing CAL in patient with Kawasaki disease.