Disrupted in Schizophrenia-1 (Disc-1), a candidate gene of schizophrenia regulates kalirin and maintains synapse.

Disc-1是精神分裂症的候选基因。随着Disc-1、动力蛋白和BBS4的发育，Disc-1的结合蛋白从中心体转移到脊柱。另一方面，r-微管蛋白和PCM-1则没有。椎间盘-1调节钾素，维持脊柱。Disc-1抑制Kalirin-7与Rac1的结合。氯氮平是治疗顽固性精神分裂症有效的非典型精神病药物之一，与NMDA受体功能有关，可使突触后标志物PSD95升高。

Disrupted in Schizophrenia-1 (Disc-1) is a candidate gene of schizophrenia. Following to the development, Disc-1, dynein and BBS4, the binding protein of Disc-1 moved from centrosome to spine. On the other hand, r-tubulin and PCM-1 did not. Disc-1 regulates kalirin and maintains spine. Disc-1 inhibited the binding of Kalirin-7 and Rac1. Clozapine, one of the atypical psychotics, which is effective to intractable schizophrenia and related to NMDA receptor function, increased PSD95, a post synaptic marker.