Behavioral physiological and molecular biological analyses of animal model for bipolar disorder

我用半年多的时间分析了一种双相情感障碍动物模型——突变的Polg1转基因小鼠的轮式跑步活动。这揭示了涉及季节性或光周期的病理生理学。我在老鼠的褪黑素合成上有了新的发现。此外，我成功地用心境稳定剂锂治疗小鼠，三个多月没有影响小鼠的健康。采用锂离子治疗的方法，研究了锂离子对模型小鼠纵向表现的影响。

I analyzed wheel-running activity of an animal model for bipolar disorder, mutant Polg1 transgenic mice, for more than a half year. This shed light on the pathophysiology involving the seasonality or photoperiodicity. I obtained novel findings on melatonin synthesis of mice. In addition, I succeeded in treating mice with lithium, a mood stabilizer, more than three months without affecting health of mice. Using the method of lithium treatment, I investigated the effect of lithium on the longitudinal manifestations of the model mice.