PD-ECGF-targeted tumor imaging with new radiolabeled uracil derivatives

与正常组织相比，血管生成因子PD-ECGF/TP在多种实体瘤中表达水平较高。在本研究中，我们旨在开发用于血管生成成像的放射性药物。为了开发一种用于血管生成成像的放射探针，我们设计并合成了一种基于尿嘧啶的放射标记PD-ECGF/TP抑制剂BOMU和IIMU。这些放射性标记的尿嘧啶衍生物在表达PD-ECGF/ tp的肿瘤中显示出高特异性积累。这些发现表明，放射性标记尿嘧啶作为一种新的单光子发射计算机断层扫描（SPECT）探针用于肿瘤血管生成成像值得进一步评价。

The angiogenic factor PD-ECGF/TP is expressed at high levels in a variety of solid tumors compared with normal tissue. In this study, we aimed at the development of radiopharmaceuticals for imaging of angiogenesis. To develop a radioprobe for angiogenesis imaging, a radiolabeled uracil-based PD-ECGF/TP inhibitor, BOMU and IIMU were designed and radiosynthesized. These radiolabeled uracil derivatives showed high and specific accumulation of in PD-ECGF/TP-expressing tumors. These finding indicate that radiolabeled uracil deserves further evaluation as a novel single photon emission computed tomography (SPECT) probe for imaging of tumor angiogenesis.