Development of human lung cancer model using NOD/SCID/γC null mouse

使用 NOD/SCID/γC null 小鼠建立人类肺癌模型

• 批准号: 20790999
• 负责人: INOUE Yoshimasa
• 金额: $ 2.66万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790999/
• 关键词: NOG mouse; MRI (magnetic resonace imageing); 非小細胞肺癌; NOGマウス; MRI; 正所性移植モデル; Comuted tomograhy(CT)

We studied a noninvasive method to evaluate tumor growth in the lung of mice. Xenotransplant model of lung cancer (NSCLC) using NOD/SCID/γcnull (NOG) mice was developed by tail vain injection of human lung cancer cell line (A549). The lung consolidation detected by MRI (magnetic resonace imageing) deteriorated in parallel with intrapulmonary tumor growth. MRI may be useful to noninvasively evaluate tumor growth in lung of mice.

我们研究了一种评估小鼠肺部肿瘤生长的无创方法。通过尾空注射人肺癌细胞系A549，建立NOD/SCID/γ - cnull （NOG）小鼠异种移植肺癌（NSCLC）模型。MRI（磁共振成像）显示肺实变与肺内肿瘤生长同时恶化。MRI可用于无创评价小鼠肺肿瘤的生长。