Protective Actions of Adiponectin on Cerebral Ischemia-reperfusion Injury.

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Adiponectin is a fat-derived plasma protein that has beneficial actions on cardiovascular disorders. Low level of plasma adiponectin is associated with increased mortality following ischemic stroke. However, the causal role of adiponectin in ischemic stroke is unknown. APN-KO mice exhibited enlarged brain infarction and increased neurological deficits following ischemia-reperfusion compared with WT mice. Conversely, adenovirus-mediated supplementation of adiponectin significantly reduced cerebral infarct size in WT and APN-KO mice. APN-KO mice showed decreased cerebral blood flow during ischemia by laser speckle flowmetry methods. These data provide a novel evidence that adiponectin exerts a cerebroprotective action. Adiponectin could represent a molecular target for the prevention of ischemic stroke