The role of VIP in pulmonary hypertension and application for the gene therapy

VIP在肺动脉高压中的作用及其在基因治疗中的应用

• 批准号: 20791088
• 负责人: KAWAKAMI Hiromasa
• 金额: $ 2.75万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791088/
• 关键词: VIP; PACAP; PAC1受容体; 肺高血圧; プラスミドベクター; 先天性肺疾患; 遺伝子治療; 肺高血圧症; 先天性心疾患

Pulmonary hypertension (PH) is critical disease. It has been reported that neuropeptides VIP, PACAP involve in pulmonary circulation and respiratory system, however, their functions are not fully elucidated. The contents of VIP and PACAP in the lung decreased in experimental PH, while the expression of their receptors VPAC1, VPAC2 and PAC1 increased. Similar results were obtained from cardiac tissue. To verify the hypothesis that replacement of the peptides may improve PH, we constructed plasmid vector encoding VIP or PACAP. We have been investigating the more efficient method to deliver the plasmid and the effect in PH.

肺动脉高压（PH）是一种危重病。已有研究表明VIP、PACAP等神经肽参与肺循环和呼吸系统，但其功能尚未完全阐明。实验性PH肺组织VIP和PACAP含量降低，其受体VPAC 1、VPAC 2和PAC 1表达增加。从心脏组织中获得了类似的结果。为了验证替换肽可以改善PH的假设，我们构建了编码VIP或PACAP的质粒载体。我们一直在研究更有效的方法来传递质粒和PH的效果。

项目成果

Altered Expression of VIP/VPAC2 in Hypertrophic Right Ventricle Induced with Monocrotaline in Rats

野百合碱诱导大鼠肥厚性右心室中 VIP/VPAC2 表达的改变

• 发表时间: 2009

Effect of Hemin on Pulmonary Artery Pressure of monocrotaline-induced pulmonary hypertension in rats.

血红素对野百合碱诱导的肺动脉高压大鼠肺动脉压的影响。

• 发表时间: 2008
• 作者: Hiromasa Kawakami;Yusuke Mizuno;Mokazu Koga;Takahisa Goto.
• 通讯作者: Takahisa Goto.

Attenuation of monocrotaline-induced pulmonary hypertension by heme oxygenase-1 involves toll-like receptor 4 signalings

血红素加氧酶 1 减弱野百合碱诱导的肺动脉高压涉及 Toll 样受体 4 信号传导

• 发表时间: 2010
• 作者: Hiromasa Kawakami;Yusuke Mizuno;Mokazu Koga;Takahisa Goto.
• 通讯作者: Takahisa Goto.

Effect of Hemin on Pulmonary Artery Pressure of Monocrotaline-Induced Pulmonary Hypertension in Rats

氯化血红素对野百合碱性肺动脉高压大鼠肺动脉压的影响

• 发表时间: 2009
• 作者: 川上裕理

実験的肺高血圧症におけるtoll-like receptor 4の関与とHeme oxygenase-1によるその抑制

Toll样受体4在实验性肺动脉高压中的作用及其对血红素氧合酶1的抑制作用

• 发表时间: 2011
• 作者: 水野祐介;川上裕理;古賀資和;後藤隆久
• 通讯作者: 後藤隆久