Which oxidative-stress marker can be the index of the brain ischemia-reperfusion injury?

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We demonstrated that 3-nitrotyrosine and 8-nitroguanosine, which are cytotoxic markers from the cerebral infarction cite, are not appropriate as markers of the cerebral ischemia-reperfusion injury. We also demonstrated that glycyrrhizin acid decreased an infarct size in a rat middle cerebral artery occlusion model, and that improved a neurological scoring. However, there was no correlation between neurological scoring and HMGB1 in cerebrospinal fluid, which was expected as a marker. HMGB1 in cerebrospinal fluid does not reflect the brain ischemia and damage, at least, in a rat middle cerebral artery occlusion model. Further investigation is required to confirm the possibility of HMGB1 as the marker of the cerebral ischemia-reperfusion injury.