Enhancement of chemo-sensitivity by molecular-targeting drugs in gemcitabine-resistant advanced bladder cancer.
Enhancement of chemo-sensitivity by molecular-targeting drugs in gemcitabine-resistant advanced bladder cancer.
批准号:
20791108
负责人:
MURAMAKI Mototugu
金额:
$1.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
Clusterin在膀胱癌细胞耐药表型的获得中发挥着重要作用,OGX-011联合化疗药物灭活Clusterin可能是通过增强化疗敏感性来治疗晚期膀胱癌的一种有吸引力的方法。
英文摘要
Clusterin plays significant role in the acquisition of chemo-resistant phenotype in bladder cancer cells and the inactication of Clusterin using OGX-011 combined with chemotherapeutic agent could be an attractive approach for advanced bladder cancer through the enhancement of chemo-sensitivity.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1111/j.1464-410x.2008.08098.x
发表时间:
2009-02-01
期刊:
BJU INTERNATIONAL
影响因子:
4.5
作者:
[Muramaki, Mototsugu, So, Alan, Gleave, Martin E.]
通讯作者:
Gleave, Martin E.
Chemosensltization of gemeltablne-reslstant human bladder cancer cell line both in vitro and in vivo using antisense oligonucleotide targeting the anti-apoptotic gene, clusterin
使用靶向抗凋亡基因簇蛋白的反义寡核苷酸对耐吉美替比的人膀胱癌细胞系进行体外和体内化学增敏
DOI:
--
发表时间:
2009
期刊:
BJU Int 103
影响因子:
--
作者:
[Muramaki M, So A, Hayashi N, Sowery R, Miyake H, Fujisawa M, Gleave ME]
通讯作者:
Gleave ME
Chemosensitization of gemcitabine-resistant human bladder cancer cell line both in vitro and in vivo using antisense oligonucleotide targetting the anti-apoptotic gene, clusterin.
使用针对抗凋亡基因簇蛋白的反义寡核苷酸对吉西他滨耐药的人膀胱癌细胞系进行体外和体内化学增敏。
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Muramaki M, So A, Hayashi N, Sowery R, Miyake H, Fujisawa M, Gleave ME, 村蒔基次]
通讯作者:
村蒔基次