Enhancement of chemo-sensitivity by molecular-targeting drugs in gemcitabine-resistant advanced bladder cancer.

分子靶向药物增强吉西他滨耐药晚期膀胱癌的化疗敏感性。

• 批准号: 20791108
• 负责人: MURAMAKI Mototugu
• 金额: $ 1.5万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791108/
• 关键词: 膀胱癌; ジェムシタビン抵抗性; 分子標的薬; ジェムシタビン; 抗癌剤耐性; 分子標的治療; アポトーシス; in vivo study; Clusterin

Clusterin plays significant role in the acquisition of chemo-resistant phenotype in bladder cancer cells and the inactication of Clusterin using OGX-011 combined with chemotherapeutic agent could be an attractive approach for advanced bladder cancer through the enhancement of chemo-sensitivity.

Clusterin在膀胱癌细胞耐药表型的获得中发挥着重要作用，OGX-011联合化疗药物灭活Clusterin可能是通过增强化疗敏感性来治疗晚期膀胱癌的一种有吸引力的方法。

项目成果

Chemosensitization of gemcitabine-resistant human bladder cancer cell line both in vitro and in vivo using antisense oligonucleotide targeting the anti-apoptotic gene, clusterin

• DOI: 10.1111/j.1464-410x.2008.08098.x
• 发表时间: 2009-02-01
• 期刊: BJU INTERNATIONAL
• 影响因子: 4.5
• 作者: Muramaki, Mototsugu;So, Alan;Gleave, Martin E.
• 通讯作者: Gleave, Martin E.

Chemosensltization of gemeltablne-reslstant human bladder cancer cell line both in vitro and in vivo using antisense oligonucleotide targeting the anti-apoptotic gene, clusterin

使用靶向抗凋亡基因簇蛋白的反义寡核苷酸对耐吉美替比的人膀胱癌细胞系进行体外和体内化学增敏

• 发表时间: 2009
• 期刊: BJU Int 103
• 作者: Muramaki M;So A;Hayashi N;Sowery R;Miyake H;Fujisawa M;Gleave ME
• 通讯作者: Gleave ME

Chemosensitization of gemcitabine-resistant human bladder cancer cell line both in vitro and in vivo using antisense oligonucleotide targetting the anti-apoptotic gene, clusterin.

使用针对抗凋亡基因簇蛋白的反义寡核苷酸对吉西他滨耐药的人膀胱癌细胞系进行体外和体内化学增敏。

• 发表时间: 2007
• 作者: Muramaki M;So A;Hayashi N;Sowery R;Miyake H;Fujisawa M;Gleave ME;村蒔基次
• 通讯作者: 村蒔基次