The contribution of cyclin dependent kinase inhibitor p57 to prostate cancer hormone resistance

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The androgen receptor occurs the prostate cancer in the androgen dependence by the nuclear receptor that belongs to the steroid receptor, and takes part in proliferation. It has decreased in the androgen dependency prostate cancer cell though cyclin E and cyclin D1 that was the positive cell cycle restrictor admitted the high expression by the androgen non-dependency prostate cancer cell. On the other hand, the appearance of cyclin dependent kinase inhibitor p57 that is a negative restrictor has decreased obviously by the androgen non-dependency prostate cancer cell. Also as for the prostate tissue immunity dye, the appearance of p57 decreased in the prostate cancer leision compared with the prostate normal leision, and the appearance of p57 was hardly admitted in the prostate cancer leision that had become a hormone resistance.