The application of new bladder cancer marker protein,peripurakin, to urinary cytology and functional analysis.

通过对膀胱癌大分子质量的蛋白质组学分析，我们发现了一种新的肿瘤标记蛋白——periplakin。我们的目的是建立尿液的非关键检查方法，并在免疫组织化学分析中检查PPL的外观。在本研究中，与对照组相比，癌症患者组尿液中移位上皮细胞出现的PPL明显减少。因此，将PPL免疫染色与泌尿细胞学结合使用，以提高诊断的可能性。

We found the novel cancer marker protein, periplakin, which disappeared appearance by proteomics analysis of the large molecular weight in bladder cancer. We aimed to establish the noncritical inspection method in urine and examining the PPL appearance in the immunohistochemical analysis. In this study, PPL appearance by the shift epithelial cell in urine has significantly decreased in the cancer patient group compared with the control group. Consequently, it was done by immunostaining of PPL and urinary cytology and using it together the possibility of improving the diagnosis.