The study of mucosal immunity in murine allergic rhinitis model
The study of mucosal immunity in murine allergic rhinitis model
批准号:
20791206
负责人:
TANAKA Norimitsu
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
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英文摘要
Phosphorylcholine (PC), which is a structural component of wide variety of bacteria, inhibits the allergic response in the upper respiratory tract in murine allergic rhinitis model. PC-pretreated mice showed mild allergic nasal symptoms. The levels of total IgE were significantly lower in PC-pretreated mice. The IL-4 production by splenic CD4+ T cells was inhibited by PC-pretreatment. Thus, PC might be useful for the development of new immunotherapeutic strategies of allergic disease.
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Mucosal and systemic immune response induced by sublingual immunization with phosphorylcholine.
磷酸胆碱舌下免疫诱导粘膜和全身免疫反应。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Shimazu Rintaro, Kusano Kenichiro, Kuratomi Yuichiro, et.al., Norimitu Tanaka]
通讯作者:
Norimitu Tanaka
Sublingual immunization with phosphorylcholine has a potential of broad spectrum vaccine against upper airaway infections.
舌下含服磷酸胆碱具有针对上呼吸道感染的广谱疫苗的潜力。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Shimazu R, Kusano K, Kuratomi Y, Inokuchi A, Norimitu Tanaka]
通讯作者:
Norimitu Tanaka
Phosphorylcholine経鼻・舌下投与における免疫応答の相違点
鼻腔和舌下含服磷酸胆碱的免疫反应差异
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[田中紀充, 早水佳子, 宮下圭一, 福山聡, 黒野祐一]
通讯作者:
黒野祐一
Phosphorylcholine(PC)経鼻・舌下投与における免疫応答の相違点
鼻腔和舌下含服磷酸胆碱 (PC) 的免疫反应差异
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[草野謙一郎, 倉富勇一郎, 徳永藏, 島津倫太郎, 井之口昭, 田中紀充]
通讯作者:
田中紀充
Sublingual immunization with phosphorylcholine has a potential of broad spectrum vaccine against upper airway infections.
舌下含磷酰胆碱免疫具有针对上呼吸道感染的广谱疫苗的潜力。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[田中紀充, 黒野祐一, et al]
通讯作者:
et al
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