中耳炎、鼻窦炎粘液细胞化生机制的基础研究。-猫眼课题宝

中耳炎、鼻窦炎粘液细胞化生机制的基础研究。

批准号：

20791212

负责人：

NAKAMURA Yoshihisa

金额：

$2.5万

依托单位：

Nagoya City University

依托单位国家：

日本

项目类别：

Grant-in-Aid for Young Scientists (B)

财政年份：

2008

资助国家：

日本

项目状态：

已结题

起止时间：

2008 至 2009

来源：

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791212/

关键词：

杯細胞化生 Math1 TNF-α レチノイン酸 EGFR Tnf-α TNF・α

项目摘要

项目成果

NAKAMURA Yoshihisa的其他基金

相似基金

相关文献

中文摘要

翻译

A key issue in otitis media(OM)is mucous cell metaplasia，a condition for hyperproduction of mucus in the middle ear mucosa and development of chronic OM.We demonstrated that Math1，a critical transcription factor for the development of mucous cells in the intestine，in the presence of pro-inflammatory cytokine(tumor necrotic factor alpha，TNF·)and retinoic acid(RA)，promoted the differentiation of middle ear epithelial cells(MEECs)into mucus cells。RA strengthened the expression of Math1via the epidermal growth factor receptor(EGFR)tyrosine kinase activity。A specific inhibitor for EGFR tyrosine kinase，AG1478，abrogated the Math1expression and reduced mucus cell numbers.Math1 or EGFR tyrosine kinase should be the therapeutic molecular target for the OM.

英文摘要

A key issue in otitis media (OM) is mucous cell metaplasia, a condition for hyperproduction of mucus in the middle ear mucosa and development of chronic OM. We demonstrated that Math1, a critical transcription factor for the development of mucous cells in the intestine, in the presence of pro-inflammatory cytokine (tumor necrotic factor alpha, TNF・) and retinoic acid (RA), promoted the differentiation of middle ear epithelial cells (MEECs) into mucus cells. RA strengthened the expression of Math1 via the epidermal growth factor receptor (EGFR) tyrosine kinase activity. A specific inhibitor for EGFR tyrosine kinase, AG1478, abrogated the Math1 expression and reduced mucus cell numbers. Math1 or EGFR tyrosine kinase should be the therapeutic molecular target for the OM.

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会议论文

Math1 drives the differentiation of middle ear epithelial cells into mucous cells in vitro.

Math1 在体外驱动中耳上皮细胞分化为粘液细胞。

DOI： --

发表时间： 2009

期刊：

影响因子： --

作者：

[Ozawa S, Kato Y, Ito S, Komori R, Shiiki N, Tsukinoki K, Ozono S, Maehata Y, Taguchi T, Imagawa-Ishiguro Y, Tsukuda M, Kubota E, Hata R, Yoshihisa Nakamura]

通讯作者： Yoshihisa Nakamura

Mathl drives the differentiation of middle ear epithelial cells into mucous cells in vitro.

Mathl 在体外驱动中耳上皮细胞分化为粘液细胞。

DOI： --

发表时间： 2009

期刊：

影响因子： --

作者：

[Kondo N, Tsukuda M, Ishiguro Y, Kimura M, Fujita K, Sakakibara A, Takahashi H, Toth G, Matsuda H, 中村善久]

通讯作者：中村善久

肺炎球菌ペプチドグリカンーポリサッカライドによる中耳粘膜肺細胞化生

肺炎球菌肽聚糖-多糖引起的中耳粘膜肺细胞化生