A novel molecular paradigm of age-related macular degeneration in view of the social trend in nocturnal: An approach using an animal model

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Age-related macular degeneration (AMD) is an ocular disease with visual dysfunction and blindness, which might be induced by sunlight exposure for a long time. Recently, our society has been going toward the nocturnal life, the number of people exposed to bright light in the nighttime has been increasing. Such the actual situation may contribute to the increased prevalence of AMD in future. A white light exposure to a rat leads to retinal dysfunction, and depending on the experimental condition, the rat goes blind, which is called as "experimental retinal photic injury model". Using this model, we investigated how risky the nocturnal exposure to blight light is and the mechanism targeted at BMAL1 protein, aiming at looking into the mechanism of the onset of AMD.