The effect of MCP-1 on the pathogenesis of giant papillae formation of the conjunctiva in vernal keratoconjunctivitis

MCP-1对春季角结膜炎结膜巨乳头形成的影响

• 批准号: 20791255
• 负责人: FUJITSU Youichiro
• 金额: $ 2.75万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791255/
• 关键词: 春季カタル; 巨大乳頭; MCP-1; アレルギー; 細胞増殖; 細胞・組織; シグナル伝達

Vernal keratoconjunctivitis is characterized by giant papilla formation. Increased expression of MCP-1 was also reported in the conjunctiva of patients with vernal keratoconjunctivitis. Human conjunctival fibroblasts express CCR2, and MCP-1 stimulates both the proliferation of and the production of extracellular matrix proteins such as fibronectin, procollagen type I C-peptide and type III collagen, in the dose dependent manner by these cells through MAPK pathway.

春季角结膜炎以巨大乳头形成为特征。在春季角结膜炎患者的结膜中也报告了MCP-1表达增加。人结膜成纤维细胞表达CCR 2，MCP-1通过MAPK途径以剂量依赖性方式刺激细胞外基质蛋白如纤连蛋白、I型前胶原C肽和III型胶原的增殖和产生。

项目成果

Recovery of corneal thickness promoted by glucocorticoid administration after phacoemulsification in eyes affected by Fuchs' dystrophy

福斯营养不良眼超声乳化术后给予糖皮质激素促进角膜厚度恢复

• 发表时间: 2008
• 期刊: Japanese journal of Ophthalmology 52
• 作者: Ooto S;Tsujikawa A;Mori S;Tamura H;Yamashiro K;Yoshimura N.;Nobuhiko Chikamoto
• 通讯作者: Nobuhiko Chikamoto

後部ぶどう腫境界部に強い牽引を生じ萎縮性円孔を多発した網膜剥離の1例

葡萄肿后缘强牵引、多发萎缩孔视网膜脱离一例。

• 发表时间: 2008
• 作者: Tsujikawa A;Ojima Y;Yamashiro K;Ooto S;Tamura H;Nakagawa S;Yoshimura N.;藤津揚一朗
• 通讯作者: 藤津揚一朗