A role of LOC387715 in the pathogenesis of Age-related Macular Degeneration

LOC387715在年龄相关性黄斑变性发病机制中的作用

• 批准号: 20791253
• 负责人: TANIMOTO Seiji
• 金额: $ 2.75万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791253/
• 关键词: 眼生化学; 分子生物学; 加齢黄斑変性; 網膜色素上皮細胞; 脈絡膜新生血管; LOC387715遺伝子

We performed functional analysis of LOC387715 gene using mouse retina and cultured retinal pigment epithelium cells. We examined the relationship between choroidal neovascularization (CNV) and vascular endothelial growth factor (VEGF) that is produced in wet type AMD. About relations with LOC387715 gene, enough results are not provided about signal transmission system, but we will follow it in future and is going to clarify it about this condition.

我们使用小鼠视网膜和培养的视网膜色素上皮细胞对LOC387715基因进行了功能分析。我们研究了脉络膜新生血管（CNV）和血管内皮生长因子（VEGF）之间的关系，在湿性AMD中产生。关于与LOC387715基因的关系，关于信号传递系统还没有提供足够的结果，但我们将在未来跟踪它，并将澄清这种情况。