Functional analysis for LFA-1 and Mac-1 in STZ-induced diabetic animal model

点击翻译按钮获取中文摘要

The purpose of this study is to determine whether the function of LFA-1 and Mac-1, both of which are the counter-receptors for ICAM-1, is upregulated in an animal model of early phase of diabetic retinopathy induced by streptozotocin (STZ). The data provided no evidence showing functional upregulation of LFA-1 and Mac-1. However, PSGL-1, counter-receptor for P-selectin, seemed to be upregulated in STZ-induced diabetic animal model. The current data indicates the functional change of PSGL-1 in chronic inflammation such as diabetes.