Study of pathophysiologic significance of ectodomain shedding in the cornea
Study of pathophysiologic significance of ectodomain shedding in the cornea
批准号:
20791284
负责人:
SAKIMOTO Tohru
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Ectodomain shedding is defined as the disintegration and extracellular release of membranous protein on the cell surface. This cellular process plays a role both in the activation and inactivation of the shedding substrate of shedding, and can potentially change functional characteristics of the substrate. In the cornea, we elucidated that ectodomain shedding is mainly activated in corneal epithelium, and soluble form of TNFR1 and IL-6R is produced from corneal epithelium. We speculated that this process plays an indispensable role in corneal wound healing and reducing inflammatory reactions.
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円錐角膜におけるADAMファミリーを介する蛋白発現の検討
ADAM 家族介导的圆锥角膜蛋白表达的检查
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[菅谷哲史, 崎元暢, 澤充]
通讯作者:
澤充
Regulation of soluble IL-6 receptor release from corneal epithelial cell by ectodomain shedding and mRNA splicing.
通过胞外域脱落和 mRNA 剪接调节角膜上皮细胞可溶性 IL-6 受体的释放。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Sakimoto T, Sugaya S, Ohnishi T, Shoji J, Sawa M]
通讯作者:
Sawa M
角膜上皮-実質相互作用におけるIL-6トランスシグナリングの役割
IL-6 反式信号传导在角膜上皮-基质相互作用中的作用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[崎元暢, 澤充]
通讯作者:
澤充
Regulation of soluble interleukin-6(IL-6)receptor release from corneal epithelial cell and its role in ocular surface.
角膜上皮细胞可溶性白细胞介素6(IL-6)受体释放的调节及其在眼表的作用。
DOI:
--
发表时间:
期刊:
Japanese Journal of Ophthalmology
影响因子:
2.4
作者:
[Sakimoto T, Yamada A, Kanno H, Sawa M, 崎元暢, 崎元暢]
通讯作者:
崎元暢
TACE(ADAM17) dependent shedding of soluble TNF receptor in conjunc tival enithelium
结膜上皮中 TACE(ADAM17) 依赖性可溶性 TNF 受体脱落
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Sakimoto T, Yamada A, Shoji J, Sawa M, 崎元暢]
通讯作者:
崎元暢
共 18 条
Role of inflamasome in corneal inflammation
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批准号:17K11468
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2017
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负责人:SAKIMOTO Tohru
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依托单位:
The role and pathophysiologic significance of IL-6 trans-signaling in the cornea
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批准号:23792010
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$1.58万
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财政年份:2011
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负责人:SAKIMOTO Tohru
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依托单位:
海外基金