New treatment of peri-implantitis with ointment which combine the effects of anti-inflammation and bone regeneration.

结合抗炎和骨再生作用的软膏治疗种植体周围炎的新方法。

• 批准号: 20791430
• 负责人: MORIYAMA Yasuko
• 金额: $ 2.66万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791430/
• 关键词: インプラント周囲炎; スタチン; 骨再生; 抗炎症

We try to make the ointment which had anti-inflammation and bone reproduction as a treatment for peri-implantites. It has been demonstrated that HMG-CoA reductase inhibitors ("statins"), which are widely used for cholesterol lowering, stimulates bone formation. And we previously showed that local application of fluvastatin at the implant site enhanced the osteogenesis around the titanium implant in early stages of healing. In addition, it has been reported that statin has anti-inflammatory effect, and transdermal application of statin promoted bone volume in rats model (Gutierrez at al. 2006). The aim of the present study was to investigate the effects of statin-containing ointment on peri-implant osteogenesis. The implant model in the rat mouth was able to be established. There was no differences between implant model in the rat mouth and peri-implantites model, because it was difficult to evaluate the inflammation. The selection of the ointment base was assumed to mix a high density of Statin with each ointment, and to examine the characteristic of each ointment. The amount of the sustained delivery of the Statin was examined by measuring the absorbance. As a results, white vaseline has a lots of sustained-relese of statin. It is ideal that the ointment have a longer duration of action on the animal experiment, but the condition of ointment in oral are not good and the statin-containing ointment have no effect. Therefore, it is necessary that the reexamination such as covering with the film etc. to prevent the outflow with saliva after the ointment is spread in the mouth.

我们尝试研制一种具有抗炎、促进骨再生作用的种植体周围炎的治疗药物。已经证明，广泛用于降低胆固醇的HMG-CoA还原酶抑制剂（“他汀类”）刺激骨形成。我们以前的研究表明，在种植体部位局部应用氟伐他汀可以在愈合的早期阶段增强钛种植体周围的骨生成。此外，据报道，他汀类药物具有抗炎作用，并且他汀类药物的经皮应用促进了大鼠模型中的骨体积（Gutierrez等人，2006）。本研究的目的是探讨他汀类软膏对种植体周围成骨的影响。建立了大鼠口腔种植模型。大鼠口腔种植体模型与种植体周围组织模型之间无差异，因为难以评价炎症。假设软膏基质的选择是将高密度的他汀类药物与每种软膏混合，并检查每种软膏的特性。通过测量吸光度来检查他汀的持续递送量。因此，白色凡士林具有大量的他汀类药物缓释作用。在动物实验中，该软膏具有较长的作用持续时间，但口服情况不佳，含他汀类药物的软膏无效果。因此，有必要重新检查，例如用薄膜覆盖等，以防止药膏在口腔中涂抹后唾液流出。

项目成果

Synergetic effect of sandblasted and acid etched surface and statin on peri-implant osteogenesis.

喷砂和酸蚀表面与他汀类药物对种植体周围成骨的协同作用。

• 发表时间: 2009
• 作者: Moriyama Y;Ayukawa Y;Ogino Y;Atsuta I;Koyano K.;Moriyama Y.
• 通讯作者: Moriyama Y.

インプラント治療における高脂血症治療薬スタチンの局所投与の効果

高脂血症药物他汀类药物局部给药在种植治疗中的效果

• 发表时间: 2008
• 作者: Y. Moriyama;Y. Ayukawa;I. Atsuta;K. Koyano;Y. Moriyama;Yasuko Moriyama;森山泰子
• 通讯作者: 森山泰子

The enhancement of peri-implant osteogenesis by local application of statin

局部应用他汀类药物促进种植体周围成骨

• 发表时间: 2008
• 作者: Y. Moriyama;Y. Ayukawa;I. Atsuta;K. Koyano;Y. Moriyama;Yasuko Moriyama
• 通讯作者: Yasuko Moriyama

Local application of fluvastatin improves peri-implant bone quality and mechanical properities: A rodent study.

氟伐他汀的局部应用可改善种植体周围的骨质量和机械性能：一项啮齿动物研究。

• 发表时间: 2010
• 期刊: Acta Biomaterialia 6
• 作者: Y. Moriyama;Y. Ayukawa;Yoichiro Ogino;Ikiru Atsuta;Mitsugu Todo;Yoshihiro Takao;Kiyoshi Koyano
• 通讯作者: Kiyoshi Koyano

Synergetic Effect of Sandblasted and Acid-Etched Surface and Statin on Peri-implant Osteogenesis in Rats.

喷砂酸蚀表面和他汀类药物对大鼠种植体周围成骨的协同作用。

• 发表时间: 2009
• 作者: Y. Moriyama;Y. Ayukawa;I. Atsuta;K. Koyano
• 通讯作者: K. Koyano