The mechanism of the enhanced sensitivityof anticancer drug andradioactive ray by the cox-2 inhibitor in oral squamous cell carcinoma

一方面，人们注意到环氧合酶(COX)在炎症组织中的表达，另一方面，近年来的研究表明COX在肿瘤的发生中起着重要的作用，COX-2在一些恶性肿瘤中被诱导高表达。在本研究中，COX-2选择性抑制剂倾向于增强抗癌药物和放射治疗对人口腔鳞癌细胞系的作用。这些结果表明，COX-2选择性抑制剂可能有助于提高口腔癌的治疗效果。

It's noted that expression of cyclooxygenase(COX) is induced in the inflammatory tissue, on the other hand, it is suggested that COX plays a significant role in oncogenesis during recent years, and high expression of COX-2 is induced in a number of the malignant neoplasm. In this study, the COX-2 selective inhibitor had tended to enhance the effect of anticancer drug and radiation against the human oral squamous carcinoma cell line. These results indicate that the COX-2 selective inhibitor may contribute to improving effect of oral cancer therapy.