The mechanism of the enhanced sensitivityof anticancer drug andradioactive ray by the cox-2 inhibitor in oral squamous cell carcinoma

COX-2抑制剂增强口腔鳞癌抗癌药物及放射线敏感性的机制

• 批准号: 20791489
• 负责人: TANIGUCHI Takahiro
• 金额: $ 2.5万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791489/
• 关键词: 臨床腫瘍学; 口腔扁平上皮癌; COX-2; アポトーシス; 抗癌剤; 放射線

It's noted that expression of cyclooxygenase(COX) is induced in the inflammatory tissue, on the other hand, it is suggested that COX plays a significant role in oncogenesis during recent years, and high expression of COX-2 is induced in a number of the malignant neoplasm. In this study, the COX-2 selective inhibitor had tended to enhance the effect of anticancer drug and radiation against the human oral squamous carcinoma cell line. These results indicate that the COX-2 selective inhibitor may contribute to improving effect of oral cancer therapy.

一方面在炎症组织中诱导COX表达，另一方面近年来提示COX在肿瘤发生中起重要作用，在许多恶性肿瘤中诱导COX-2高表达。在本研究中，COX-2选择性抑制剂有增强抗癌药物和放疗对人口腔鳞状癌细胞的作用的趋势。这些结果提示COX-2选择性抑制剂可能有助于提高口腔癌的治疗效果。