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The global analysis of N-α-acetylome that is aiming development of antitumor therapy by the target factor in oral cancer.

The global analysis of N-α-acetylome that is aiming development of antitumor therapy by the target factor in oral cancer.
N-α-乙酰组的整体分析,旨在通过口腔癌的靶因子开发抗肿瘤治疗。
批准号:
20791511
负责人:
TAKUBO Kazuko
金额:
$2.16万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009

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项目成果

TAKUBO Kazuko的其他基金

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中文摘要
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英文摘要
N-acetyltransferase human (NATH) participates in a posttranslational modification of the proteins and has been reported to play a role in apoptosis. In this study, the involvement of NATH in the cytotoxic action of 5-fluorouracil (5-FU) in human squamous cell carcinoma HEp-2 cells was examined. We found that 5-FU decreased NATH expression in a dose-dependent and time-dependent manner. No change was observed after treatment with other chemotherapeutics. The results of this study suggest that NATH plays an important role in the cytotoxic activity of 5-FU.
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DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [松本行史, 山本憲幸, 山本憲幸, Takubo K, 田窪千子, 田窪千子, 田窪 千子]
通讯作者: 田窪 千子
Involvement of N-acetyltransferase human in the cytotoxic activity of 5-fluorouracil.
人 N-乙酰转移酶参与 5-氟尿嘧啶的细胞毒活性。
DOI: --
发表时间: 2009
期刊: Anticaneer Drugs 20(8)
影响因子: --
作者: [Takubo K, Tsuchiya H, Kurimasa A, Arnesen T, Ryoke K, Shiota G.]
通讯作者: Shiota G.
Involvement of N-α-acetyltransferase human in the cytotoxic activity of 5-fluorouracil
人 N-α-乙酰转移酶参与 5-氟尿嘧啶的细胞毒活性
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [松本行史, 山本憲幸, 山本憲幸, Takubo K, 田窪千子]
通讯作者: 田窪千子
Involvement of N-α-acetyltransferase human in the antitumor effect of 5-fluorouracil
人N-α-乙酰转移酶参与5-氟尿嘧啶的抗肿瘤作用
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [松本行史, 山本憲幸, 山本憲幸, Takubo K, 田窪千子, 田窪千子, 田窪 千子, 田窪千子, 田窪 千子, 田窪千子]
通讯作者: 田窪千子
8
    The identification of the target protein of N-α-acetyltransferase and the devel opment of a newly therapy by the control of N-α-acetylome
    • 批准号:
      22791976
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.5万
    • 财政年份:
      2010
    • 负责人:
      TAKUBO Kazuko
    • 依托单位: