The Study of Protective Effect of Intravenous and Inhalation Anesthetic to Oxidative Stress in Central Nerve System

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I aimed the establishment of experimental animal model of the oxidative stress in the central nerve system (CNS) to research the protective effect of anesthetics to oxidative stress in CNS. I made the rat Hemorrhage shock model that was initiated by bleeding, kept low blood pressure for 1 hour, and returned to normal blood pressure. After that, I studied whether oxidative stress was present in CNS. In the result, I could detect the expression of Heme Oxygenase-1 that was oxidative stress-specific enzyme in CNS. This means that Hemorrhage shock model is the experimental animal model of the oxidative stress in CNS.