Expression of Apoptosis inhibitor gene, Survivin, in Human Oral Squamous Cell Carcinoma

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We received the approval of the Tokyo Dental College Ethical Review Board and we obtained its consent from 38 patients with oral squamous cell carcinoma and obtained a tumor tissue, a normal tissue. We completed extraction of the DNA in the all Also, it extracted RNA in ten people. We randomly chose three people among the RNA, and all genome cover analyzed the gene expression of the oral cavity squamous cell carcinoma patients using microarray. We randomly chose three people among the RNA, and all genome cover analyzed the gene expression of the oral cavity squamous cell carcinoma patients using Microarray. As a result, three people did not show the apoptosis association gene which they were common, and showed overexpression, a manifestation decrease. We used five oral cavity squamous cell carcinoma origin cell line in a DNA copy number of Survivin with the tumor tissue of 20 patients with oral squamous cell carcinoma, a normal tissue and analyzed gene expression of Survivin by real-time PCR. As a result, five of 20 people