Analysis of the neural regulation of the bone metabolism under the mechanical stress.

为了分析机械应力下骨代谢的神经调节，我们研究了骨激活素(OA)在人牙周膜(HPDL)细胞中的作用。当机械应力作用于大鼠磨牙时，HPDL细胞、成骨细胞和破骨细胞中均出现了骨性关节炎。当HPDL细胞受到张力时，OA的免疫反应性降低。这些结果表明，张力力诱导骨性关节炎细胞外域的释放，从而刺激张力侧的骨形成。

To analyze the neural regulation of the bone metabolism under the mechanical stress, we investigated the role of osteoactivin (OA) in the human periodontal ligament (HPDL) cells. When the mechanical stress was loaded to the rat molar, OA appeared in the HPDL cells, osteoblasts, and osteoclasts. When HPDL cells were given the tension force, the immunoreactivity of OA was reduced. These results suggested that tension forces induced the release of extracellular domain of OA, resulting in the stimulation of bone formation at the tension side.