elucidation of the molecular mechanism of angiogenesis induced by the external shockwaves and its therapeutic application for the treatment of chronic heart failure

阐明外部冲击波诱导血管生成的分子机制及其在慢性心力衰竭治疗中的应用

• 批准号: 20890016
• 负责人: NAKANO Matkoto
• 金额: $ 2.11万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (Start-up)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20890016/
• 关键词: 体外衝撃波治療法; 血管新生; 慢性心不全; 血管内皮前駆細胞

We demonstrated that shockwave treatment applied to cultured human umbilical vein endothelial cells upregulated mRNA expression of vascular endothelial growth factor, although further studies are required to determine the optimal condition of the shockwave treatment. Extracorporeal shockwave therapy to a rat model of chronic heart failure was performed, which induced a tendency to improve both left ventricular contractile function and survival rate.

我们证明，冲击波治疗应用于培养的人脐静脉内皮细胞上调血管内皮生长因子的mRNA表达，虽然需要进一步的研究，以确定冲击波治疗的最佳条件。体外冲击波治疗慢性心力衰竭大鼠模型，有改善左室收缩功能和提高存活率的趋势。

项目成果

Genetic Deletion of OX40 Ligand Suppresses the Development of Atherosclerosis in Apolipoprotein E-Deficient Mice

OX40配体的基因缺失抑制载脂蛋白E缺陷小鼠动脉粥样硬化的发展

• 发表时间: 2009
• 作者: 中野誠;下川宏明;他
• 通讯作者: 他

東北大学循環器内科ホームページ

东北大学心脏病学系主页

Statin ameliorates hypoxia-induced pulmonary hypertension associated with down-regulated stromal cell-derived factor-1

• DOI: 10.1093/cvr/cvn244
• 发表时间: 2009-01-01
• 期刊: CARDIOVASCULAR RESEARCH
• 影响因子: 10.8
• 作者: Satoh, Kimio;Fukumoto, Yoshihiro;Shimokawa, Hiroaki
• 通讯作者: Shimokawa, Hiroaki

Differential Roles of Progenitor Cells in Cardiovascular Disease

祖细胞在心血管疾病中的不同作用

• 发表时间: 2009
• 作者: 中野誠;下川宏明;他
• 通讯作者: 他

Spatial non-uniformity of excitation-contraction coupling can enhance arrhythmogenic-delayed afterdepolarizations in rat cardiac muscle

• DOI: 10.1093/cvr/cvn162
• 发表时间: 2008-10-01
• 期刊: CARDIOVASCULAR RESEARCH
• 影响因子: 10.8
• 作者: Miura, Masahito;Wakayama, Yuji;Shimokawa, Hiroaki
• 通讯作者: Shimokawa, Hiroaki