The analysis of FcRγ-independent signaling of a novel activating receptor MAIR-IV
The analysis of FcRγ-independent signaling of a novel activating receptor MAIR-IV
新型激活受体 MAIR-IV 的 FcRγ 独立信号传导分析
批准号：
20890028
负责人：
MAKANO Takako
金额：
$1.7万
依托单位：
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (Start-up)
财政年份：
2008
资助国家：
日本
项目状态：
已结题
起止时间：
2008 至 2009
中文摘要
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英文摘要
A novel activating receptor MAIR-IV associates with ITAM-bearing adopter molecule FcRγchain and regulates cell activation. We detected that MAIR-IV could also transduce activating signal in absent of FcRγ chain. Here we shows that syk is dispensable but MyD88 is indispensable in this FcRγ-independent pathway.
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