A role of dysregulated glycosylation of hypoxia-inducible factors in the pathogenesis of cardio-renal syndrome

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This study was designed to gain insight into molecular mechanisms in the pathogenesis of the cardio-renal syndrome, from a viewpoint of dysregulated glycosylation of hypoxia-inducible transcription factors. Methylglyoxal (MG) is a highly reactive metabolite and is known to accumulate in chronic kidney disease. In cell culture experiments, MG failed to impact hypoxia response. On the other hand, high glucose dampened cellular hypoxia response by approximately 20%. Results of the present study provide a clue to understanding molecular mechanisms underlying the cardio-renal syndrome as well as the metabolic syndrome.