A role of dysregulated glycosylation of hypoxia-inducible factors in the pathogenesis of cardio-renal syndrome

缺氧诱导因子糖基化失调在心肾综合征发病机制中的作用

• 批准号: 20890053
• 负责人: TANAKA Tetsuhiro
• 金额: $ 2.11万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (Start-up)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20890053/
• 关键词: 心腎連関; HIF; 糖化修飾

This study was designed to gain insight into molecular mechanisms in the pathogenesis of the cardio-renal syndrome, from a viewpoint of dysregulated glycosylation of hypoxia-inducible transcription factors. Methylglyoxal (MG) is a highly reactive metabolite and is known to accumulate in chronic kidney disease. In cell culture experiments, MG failed to impact hypoxia response. On the other hand, high glucose dampened cellular hypoxia response by approximately 20%. Results of the present study provide a clue to understanding molecular mechanisms underlying the cardio-renal syndrome as well as the metabolic syndrome.

本研究旨在从缺氧诱导转录因子糖基化失调的角度深入了解心肾综合征发病机制的分子机制。甲基乙二醛（MG）是一种高度反应性的代谢产物，已知在慢性肾脏疾病中蓄积。在细胞培养实验中，MG未能影响缺氧反应。另一方面，高葡萄糖抑制细胞缺氧反应约20%。本研究的结果提供了一个线索，以了解潜在的心肾综合征以及代谢综合征的分子机制。

项目成果

The role of hypoxia, increased oxygen consumption and HIF-1alpha in progression of chronic kidney disease

缺氧、耗氧量增加和 HIF-1α 在慢性肾病进展中的作用

• 发表时间: 2010
• 期刊: Current Opinion in Nephrology and Hypertension 19(1)
• 作者: Tanaka T;Nangaku M
• 通讯作者: Nangaku M

The role of hypoxia, increased oxygen consumption and HIF-lalpha in progression of chronic kidney disease

缺氧、耗氧量增加和 HIF-lα 在慢性肾病进展中的作用

• 发表时间: 2010
• 期刊: Current Opinion in Nephrology and Hypertension 19
• 作者: Tanaka T;Nangaku M
• 通讯作者: Nangaku M