Pathological studies on Parkinson's disease and amyotrophic lateral sclerosis

在连续2 0 4例尸检中，迷走神经背侧核α-突触核蛋白的病理改变与心交感神经酪氨酸羟基酶免疫整流物的减少密切相关。我们报道了不同肌萎缩侧索硬化症(ALS)类型的FUS病理，日本家族性ALS患者的临床和神经病理结果，具有新的TDP-43A315E突变，存在几个外周蛋白阳性的Bunina小体，以及视神经磷酸酶不仅在ALS中出现，而且在许多神经退行性疾病中也出现。

In our 204 consecutive autopsied cases, there were close relationship between α-synuclein pathology in dorsal vagal nuculei and the decrease of tyrosine hydroxylase immunorectivites in cardiac sympathetic nerves. We reported FUS pathology in various amyotrophic lateral sclerosis (ALS) types, clinical and neuropathological findings of Japanese familial ALS patients with a novel TDP-43 A315E mutation, presence of several peripherin-positive Bunina bodies, and appearance of optineurin not only in ALS but also in many neurodegenerative conditions.