Analysis of MHC restriction between hemopoietic stem cells and mesenchymal stem cells in humans and mice

脐带血来源的造血干细胞(HSC)与来自同一胎儿羊膜的间充质干细胞(MSCs)共移植可促进脐带血来源的造血干细胞(HSC)植入SCID小鼠体内。G-CSF可能在一定程度上参与了MHC相合的MSCs的优先造血支持能力。在高表达MHC-I类分子的HSC与MHC相合的MSCs共培养体系中，小鼠HSC的增殖率明显高于低表达MHC-I类分子的HSC。此外，自身免疫易感小鼠HSC的异常增殖(无MHC限制)归因于自身免疫性疾病发病后HSC上CD56分子的表达增加。

Engraftment of umbilical cord blood-derived hemopoietic stem cells (HSC) into SCID mice was facilitated when mesenchymal stem cells (MSCs) derived from the amnion of the same fetus were co-grafted. It is likely that G-CSF contributes to some extents to the preferential hemopoiesis-supporting ability of the MHC-matched MSCs. A higher proliferation of mouse HSCs was observed in co-culture system of HSCs expressing a high level of MHC class I molecule with MHC-matched MSCs than in that of HSCs expressing a low level of MHC class I molecule. Moreover, the abnormal proliferation (no MHC restriction) of HSCs in autoimmune-prone mice was attributed to increased expression of CD56 molecule on the HSC after the onset of autoimmune diseases.