Development of the new diagnosis and the new therapy for rheumatoid arthritis by microRNA
Development of the new diagnosis and the new therapy for rheumatoid arthritis by microRNA
批准号:
20591171
负责人:
NAKAMACHI Yuji
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
We investigated the possibility of microRNA as a useful diagnostic marker or therapeutic drug for the treatment of rheumatoid arthritis. We used the rat adjuvant-induced arthritis model. We found that microRNA expression profile was different between the arthritis rat and non-arthritis rat at joint tissues and in mononuclear cells. We treated the adjuvant-induced arthritis rat with miR-124 by injecting into right hind heel, and the arthritis of miR-124 injected rats subsided compared to that of control rats. These results suggested that microRNA could be useful as a new diagnostic and therapueutic tool for rheumatoid arthritis.
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関節リウマチにおける microRNA の意義と役割
microRNA在类风湿性关节炎中的意义和作用
DOI:
--
发表时间:
2010
期刊:
リウマチ科.
影响因子:
--
作者:
[河野 誠司, 中町 祐司, 熊谷 俊一.]
通讯作者:
熊谷 俊一.
免疫疾患の環境因子とエビジェネティクス
环境因素与免疫疾病的表观遗传学
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[河野誠司, 中町祐司, 熊谷俊一]
通讯作者:
熊谷俊一
miR-124a is a regulator of proliferation and MCP1 secretion in fibroblast like synoviocytes from patients with rheumatoid arthritis
miR-124a 是类风湿关节炎患者成纤维样滑膜细胞增殖和 MCP1 分泌的调节因子
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[中町祐司.河野誠司, 熊谷俊一, et al.]
通讯作者:
et al.
Quantitative Detection of PML-RARa Fusion Transcript by Real-Time PCR with A Single Primer Pair
使用单引物对进行实时 PCR 定量检测 PML-RARa 融合转录本
DOI:
--
发表时间:
2009
期刊:
J Clin Lab Anal. 23
影响因子:
--
作者:
[Takenokuchi M., Nakamachi Y., Yoneda K., Joo K., Kawano S., Tatsumi E., Saigo K., Kumagai S.]
通讯作者:
Kumagai S.
マイクロRNAと自己免疫疾患
MicroRNA与自身免疫性疾病
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[河野誠司, 中町祐司, 熊谷俊一]
通讯作者:
熊谷俊一
共 13 条
Development of the novel therapy for rheumatoid arthritis by microRNA.
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批准号:23591436
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
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财政年份:2011
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负责人:NAKAMACHI Yuji
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依托单位:
Research of the pathogenesis of arthritis rheumatoid by micro RNA and msearch of the possibility of a novel diagnosis method for arthritis rheumatoid by micro RNA
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批准号:18591109
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.55万
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财政年份:2006
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负责人:NAKAMACHI Yuji
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依托单位:
海外基金