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Study of the role of connexin 26 in metastasis of malignant melanoma and development of metastasis inhibitor

Study of the role of connexin 26 in metastasis of malignant melanoma and development of metastasis inhibitor
连接蛋白26在恶性黑色素瘤转移中的作用研究及转移抑制剂的开发
批准号:
20591325
负责人:
ASADA Hideo
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
Malignant melanoma is a tumor of the poor prognosis in which the metastasis is caused at the early stage. We previously found that connexin 26 (Cx26) took an important role in the metastasis of malignant melanoma. I aimed at the development of a molecular target medicine controlling the metastasis of malignant melanoma in this study, and tried making the antibodies for the extracellular domains of the Cx26 molecule, and examined the metastasis controlling effect of the antibodies using a malignant melanoma metastasis mouse model. As a result, the antibodies showed metastasis control action although it was not strong.
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会议论文
Adjuvant effect of lipopolysaccharide on the induction of contact hypersensitivity to haptens in mice.
脂多糖对诱导小鼠半抗原接触超敏反应的辅助作用。
DOI: --
发表时间: 2008
期刊: J Dermatol Sci 53
影响因子: --
作者: [Yokoi S, Niizeki H, Iida H, Asada H, et al]
通讯作者: et al
Pigmented lesion on the right sole, nodular melanoma with massive regression
右脚底色素性病变,结节性黑色素瘤大规模消退
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Fukumoto T, et al]
通讯作者: et al
Pigmented lesion on the right sole, nodular melanoma with massive regression.
右脚底色素沉着,结节性黑色素瘤大量消退。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Fukumoto T, Daikoku N, Kuwahara T, Kobayasi N, Asada H]
通讯作者: Asada H
Regulatory effects of antihistamines on the responses to staphylococcal enterotoxin B of human monocyte-derived dendritic cells and CD4+ T cells.
抗组胺药对人单核细胞来源的树突状细胞和 CD4 T 细胞对葡萄球菌肠毒素 B 反应的调节作用。
DOI: --
发表时间: 2008
期刊: Journal of dermatological science (Amsterdam)
影响因子: --
作者: [H. Iida, H. Asada, Shoko Yokoi, H. Niizeki, Yasuki Yasuda, S. Miyagawa, E. Kita]
通讯作者: E. Kita
14
    Development of moleculartargeted therapy for EBV-infected NK cell lymphocytosis in the patients with hypersensitivity to mosquito bites
    • 批准号:
      18591257
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.49万
    • 财政年份:
      2006
    • 负责人:
      ASADA Hideo
    • 依托单位:
    Study on the mechanism of EBV reactivation and NK cell oncogenesis in hypersensitivity to mosquito bites
    • 批准号:
      16591113
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      2004
    • 负责人:
      ASADA Hideo
    • 依托单位:
    Study on the induction mechanism of hydroa vacciniforme and hypersensitivity to mosquito bites in the Epstein-Barr virus-associated lymphoma
    Study on the role of dendritic cells in the atopic dermatitis
    • 批准号:
      11670829
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      1999
    • 负责人:
      ASADA Hideo
    • 依托单位:
    海外基金