Study of the role of connexin 26 in metastasis of malignant melanoma and development of metastasis inhibitor

连接蛋白26在恶性黑色素瘤转移中的作用研究及转移抑制剂的开发

• 批准号: 20591325
• 负责人: ASADA Hideo
• 金额: $ 3万
• 依托单位: Nara Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591325/
• 关键词: 悪性黒色腫; コネキシン26; ギャップ結合; 転移; 内皮細胞

Malignant melanoma is a tumor of the poor prognosis in which the metastasis is caused at the early stage. We previously found that connexin 26 (Cx26) took an important role in the metastasis of malignant melanoma. I aimed at the development of a molecular target medicine controlling the metastasis of malignant melanoma in this study, and tried making the antibodies for the extracellular domains of the Cx26 molecule, and examined the metastasis controlling effect of the antibodies using a malignant melanoma metastasis mouse model. As a result, the antibodies showed metastasis control action although it was not strong.

恶性黑色素瘤是一种预后不良的肿瘤，其转移是在早期引起的。我们之前发现连接蛋白26（Cx26）在恶性黑色素瘤的转移中发挥重要作用。本研究以开发控制恶性黑色素瘤转移的分子靶向药物为目标，尝试制备针对Cx26分子胞外结构域的抗体，并使用恶性黑色素瘤转移小鼠模型检测抗体的转移控制效果。结果，这些抗体显示出转移控制作用，尽管其不强。

项目成果

Adjuvant effect of lipopolysaccharide on the induction of contact hypersensitivity to haptens in mice.

脂多糖对诱导小鼠半抗原接触超敏反应的辅助作用。

• 发表时间: 2008
• 期刊: J Dermatol Sci 53
• 作者: Yokoi S;Niizeki H;Iida H;Asada H;et al
• 通讯作者: et al

Pigmented lesion on the right sole, nodular melanoma with massive regression

右脚底色素性病变，结节性黑色素瘤大规模消退

• 发表时间: 2010
• 作者: Fukumoto T;et al
• 通讯作者: et al

Pigmented lesion on the right sole, nodular melanoma with massive regression.

右脚底色素沉着，结节性黑色素瘤大量消退。

• 发表时间: 2010
• 作者: Fukumoto T;Daikoku N;Kuwahara T;Kobayasi N;Asada H
• 通讯作者: Asada H

Regulatory effects of antihistamines on the responses to staphylococcal enterotoxin B of human monocyte-derived dendritic cells and CD4+ T cells.

抗组胺药对人单核细胞来源的树突状细胞和 CD4 T 细胞对葡萄球菌肠毒素 B 反应的调节作用。

• 发表时间: 2008
• 期刊: Journal of dermatological science (Amsterdam)
• 作者: H. Iida;H. Asada;Shoko Yokoi;H. Niizeki;Yasuki Yasuda;S. Miyagawa;E. Kita
• 通讯作者: E. Kita

Relationship among human herpesvirus 6 reactivation. serum interleukin-10 levels, and skin rash / GVHD after allogeneic stem cell transplantation.

人类疱疹病毒6型再激活之间的关系。

• 发表时间: 2008
• 期刊: J Am Acad Dermatol 58
• 作者: Kitamura K;Asada H;et al
• 通讯作者: et al