Roles of antimicrobial agents Psoriasin and Dermcidin in skin innate immunity

除了人β-防御素和LL-37之外，皮肤组织还产生其他抗微生物剂，包括牛皮癣素、杀皮素和catestatin。在本研究项目中，我们发现上述抗菌剂激活和调节人角质形成细胞和肥大细胞的各种功能。因此，皮肤源性抗菌剂除了具有杀菌特性外，还可能参与皮肤宿主防御、炎症和先天免疫系统。

In addition to human β-defensins and LL-37, the cutaneous tissue also generates other antimicrobial agents, including psoriasin, dermcidin and catestatin. In this study project, we found that above antimicrobial agents activate and regulate various functions of human keratinocytes and mast cells. Thus, besides their microbiocidal properties, skin-derived antimicrobial agents might also participate in cutaneous host defense, inflammation and innate immune system.