Physiology and application of deimination of humnan hair follicle S100A3
Physiology and application of deimination of humnan hair follicle S100A3
批准号:
20591358
负责人:
KAWADA Akira
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
S100A3 protein specifically expressed in the cuticular cells of hair follicle. Human S100A3 is characterized by two disulphide bridges, a preformed Zn^<2+>-binding site, and a specific citrullination site by deimination. Conversion to the citrulline residues, symmetrically located on the S100A3 dimer plane-causes the assembly of the Ca^<2+>-bound S100A3 homotetramer. S100A3 acts as a Ca^<2+> buffering protein providing Ca^<2+> ions in turn to the deimination.
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Refined crystal structure of human Ca^2+/Zn^<2+>-binding S100A3 protein characteraized by two disulphide bridges
以两个二硫桥为特征的人 Ca^2 /Zn^2 > 结合 S100A3 蛋白的精制晶体结构
DOI:
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发表时间:
期刊:
J.Mol.Biol. (In press)
影响因子:
--
作者:
[M.Unno, T.Kawasaki, H.Takahara, C.W.Heizmann, K.Kizawa]
通讯作者:
K.Kizawa
Specific Citrullination Causes Assembly of a Globular SI00A3 Homotetramer : A Putative Ca2+-Modulator Matures Human Hair Cuticle
特定的瓜氨酸化导致球状 SI00A3 同源四聚体的组装:一种假定的 Ca2 调节剂使人的头发角质层成熟
DOI:
--
发表时间:
2008
期刊:
J. Biol. Chem. 283
影响因子:
--
作者:
[Nakajima T, Inui S, Fushimi T, Noguchi F, Itami S., Kizawa K]
通讯作者:
Kizawa K
Transcriptional regulation of peptidylarginine deiminase expression in human keratinocytes
人角质形成细胞中肽基精氨酸脱亚胺酶表达的转录调控
DOI:
--
发表时间:
2009
期刊:
J.Dermatol.Sci. 53
影响因子:
--
作者:
[S.Ying, S.Dong, A.Kawada, T.Kojima, S.Chavanas, M.C.Mechin, V.Adoue, G.Serre, M.Simon, H.Takahara]
通讯作者:
H.Takahara
An intronic enhancer driven by NF-_KB contributes to transcriptional regulation of peptidylarginine deiminase type I gene in human keratinocytes.
由 NF-_KB 驱动的内含子增强子有助于人角质形成细胞中肽基精氨酸脱亚胺酶 I 型基因的转录调节。
DOI:
--
发表时间:
期刊:
J Invest Dermatol. 201
影响因子:
--
作者:
[S.Ying, T.Kojima, A.Kawada, R Nachat, G.Serre, M.Simon, H Takahara]
通讯作者:
H Takahara
DOI:
10.1074/jbc.m709357200
发表时间:
2008-02-22
期刊:
JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子:
4.8
作者:
[Kizawa, Kenji, Takahara, Hidenari, Heizmann, Claus W.]
通讯作者:
Heizmann, Claus W.
共 6 条
Regulatory Mechanism of Peptidylarginine Deiminase Genes Expressed in the Human Epidermal Cells
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批准号:18591265
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.57万
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财政年份:2006
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负责人:KAWADA Akira
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依托单位: