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Involvement of opioid system in nicotine and alcohol dependence

Involvement of opioid system in nicotine and alcohol dependence
阿片类药物系统参与尼古丁和酒精依赖
批准号:
20591376
负责人:
KISHIOKA Shiroh
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
In this study, we investigated the role of endogenous opioid system in physical dependence induced by nicotine or alcohol. Treatment of opioid receptor antagonist, naloxone caused withdrawal symptoms in mice administered nicotine twice a day for 5-9 days. Nicotine dependence was suppressed by opioid receptor antagonist, naltrexone. On the other hand, treatment of naloxone caused withdrawal symptoms in mice given water including ethanol (1%). These results suggest that endogenous opioid system plays an important role in physical dependence induced by nicotine or alcohol.
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会议论文
Leptin and neuropathic pain.
瘦素和神经性疼痛。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Kishioka S, Maeda T]
通讯作者: Maeda T
Nicotine stimulates opioid system through the activation of nicotinic acetylcholine receptor.
尼古丁通过激活烟碱乙酰胆碱受体刺激阿片系统。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Kishioka S, Ueno K, Yamamoto C, Yamamoto A, Saika F, Iwai S, Kobayashi Y, Kiguchi N, Maeda T]
通讯作者: Maeda T
ニコチンの抗侵害刺激効果および身体依存形成能における内因性オピオイド系の関与
内源性阿片系统参与尼古丁的抗伤害作用及其形成身体依赖性的能力
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [小林悠佳, 他]
通讯作者:
Effects of peroxisome proliferator-activated receptor gamma agonist on the neuropathic pain induced by partial sciatic nerve ligation in mice.
过氧化物酶体增殖物激活受体γ激动剂对小鼠部分坐骨神经结扎引起的神经病理性疼痛的影响。
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Kishioka S, Maeda T, Kiguchi N, Kobayashi Y]
通讯作者: Kobayashi Y
50
    Identification of crosstalk between pathological angiogenesis and neurons in regulating chronic pain
    • 批准号:
      24590730
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.41万
    • 财政年份:
      2012
    • 负责人:
      KISHIOKA Shiroh
    • 依托单位:
    海外基金