Involvement of interaction between RNA and protein in neurodegenerative mechanisms in dementia

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To elucidate involvement of interaction between RNA and protein in neurodegenerative processes, ribotoxic stress was added by oxidative stress, and phosphorylation of tau and activation of JNK and p38 MAPK were revealed. And, TLR-3, an innate immune receptor that can bind to double stranded RNA, was also investigated in disease brain, including Alzheimer disease and amyloid-transgenic mice Tg2576. Expression of TLR-3 was significantly increased in Alzheimer disease and Tg2576, and TLR-3 positive cells were distributed in and around amyloid plaques. In these neurodegenerative processes, oxidation of rRNA or release of RNA from dead cells, might be involved.