Contrast enhancement of pancreatic carcinoma on dynamic CT : correlation between expression of VEGF and histopathological features

胰腺癌动态CT增强对比：VEGF表达与组织病理学特征的相关性

• 批准号: 20591436
• 负责人: GABATA Toshifumi
• 金额: $ 1.91万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591436/
• 关键词: エックス線; CT; 膵管癌; 膵腺管癌; ダイナミックCT; VEGF; MVD; 膵癌腫瘍内線維化

To evaluate retrospectively the correlation between enhancement patterns on dynamic computed tomography (CT) and angiogenesis and fibrosis in pancreatic adenocarcinoma. The tumors with greater MVD and higher expression of VEGF tended to show high enhancement in the arterial dominant phase. On the other hand, the tumors with a larger amount of fibrosis showed a negative correlation with the grade of enhancement during the arterial phase. In conclusion, enhancement patterns on dynamic CT correlated with angiogenesis and may be modified by the extent of fibrosis.

回顾性评估动态计算机断层扫描 (CT) 增强模式与胰腺腺癌血管生成和纤维化之间的相关性。 MVD较大且VEGF表达较高的肿瘤往往在动脉显性期表现出高度强化。另一方面，纤维化量较大的肿瘤与动脉期强化程度呈负相关。总之，动态 CT 的增强模式与血管生成相关，并且可能会因纤维化的程度而改变。

项目成果

IgG4-related Lung and Pleural Disease: A Clinicopathologic Study of 21 Cases

• DOI: 10.1097/pas.0b013e3181bd535b
• 发表时间: 2009-12-01
• 期刊: AMERICAN JOURNAL OF SURGICAL PATHOLOGY
• 影响因子: 5.6
• 作者: Zen, Yoh;Inoue, Dai;Nakanuma, Yasuni
• 通讯作者: Nakanuma, Yasuni

Radiological and histopathological manifestations of hepatocellular nodular lesions concomitant with various congenital and acquired hepatic hemodynamic abnormalities

伴有各种先天性和获得性肝血流动力学异常的肝细胞结节性病变的放射学和组织病理学表现

• 发表时间: 2009
• 期刊: Jpn J Radiol 27
• 作者: Kobayashi Y;Matsui O;Gabata T;et al.
• 通讯作者: et al.

Imaging diagnosis of hepatic metastases of pancreatic carcinoinas : significance of transient wedged-shaped contrast enhan cement mimicking arterioportal shunt.

胰腺癌肝转移的影像诊断：模拟动脉门静脉分流的瞬时楔形增强骨水泥的意义。

• 发表时间: 2008
• 期刊: Abdominal Imaging 33
• 作者: Gabata T;et al.
• 通讯作者: et al.

胆膵疾患のMRI診断:MRIをやってよかった症例を中心に

胆胰疾病的MRI诊断：聚焦MRI成功案例

• 发表时间: 2010
• 作者: Shigeki Ito;Hiroyuki Kurosawa;Hiroyuki Kasaha;Satomi Teraoka;Eiji Ariga;Shizuhiko Deji;Masahiro Hirota;Takuya Saze;Takao Minamizawa;Kunihide Nishizaw;蒲田敏文;蒲田敏文
• 通讯作者: 蒲田敏文

Optimal imaging of hepatic mass lesions

肝脏肿块病变的最佳成像

• DOI: 10.1111/j.1440-1746.2008.05647.x
• 发表时间: 2008
• 期刊: Journal of Gastroenterology and Hepatology
• 影响因子: 4.1
• 作者: O. Matsui;T. Gabata;Satoshi Kobayashi
• 通讯作者: Satoshi Kobayashi