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超高分解能CTを用いた肺末梢リモデリングの形態解析と末梢換気に及ぼす影響の検討

超高分辨率CT对周围肺重塑的形态学分析及其对周围通气的影响

基本信息

批准号：
20591462
负责人：
居倉博彦
金额：
$ 2.33万
依托单位：
Tokai University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2008
资助国家：
日本
起止时间：
2008 至 2010
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591462/
关键词：
肺末梢構造超高分解能CT リモデリング末梢換気放射線放射光CT

项目摘要

1.研究計画の概要我々は超高分解能CTであるMicro-Focus X-ray CT(MFXCT)に注目し、放射光CT研究と平行してMFXCTを用いた肺末梢構造描出の研究を開始した。MFXCTは撮像時間が短く,大量のデータを短時間で得ることが可能である。平成20年度では、肺末梢構造の2-D MFXCT像を対応する病理組織像およびSRCT像と対比することで、MFXCT像の解剖・病理学的成り立ちを解明し、各肺疾患の病理学的特徴を明らかにすることとした.2.研究の進捗状況正常および病理を有する肺を用い,現在,MFXCT撮像中で,漸次SRCTおよび病理組織像との対応を行っている.3.現在までの達成度正常肺では,SRCTに匹敵する,空間分解能約10μmの画像が得られ,肺末梢構造の描出に優れていることが,再確認された.病理を有する肺では,肺線維症や肺気腫肺で,そのremodelingが2-Dで明らかになり,末梢換気への影響が示唆される所見が多く観察されている.肺炎や肺がん標本での観察も行った.また放射光CTで行った3-D構築をMFXC丁に応用し,立体構築を行っている.4.今後の研究の推進方策データの蓄積とともに,所見を整理し,2-Dでのremodelingの形態的特徴をまとめる.また,平成22年度においては,MFXCTにおける3-D構築について,描出方法を確立するとともに,基礎的解析を展開し.換気における形熊変化の影響についても検討したい.

1. Summary of the research project I analyzed the ultra-high decomposition energy CT the Micro-Focus X-ray CT (MFXCT) attention, the radiation CT study parallel imaging MFXCT imaging using lung endings to trace the beginning of the study. The time of MFXCT video summarization is short, and a large number of customers may be unable to buy video in a short period of time. In Pingcheng, 2-D MFXCT images of lung periphery were performed in Pingcheng in 2000.The pathological tissue images of lung diseases were compared with those of lung diseases, and the pathological features of various lung diseases were analyzed by MFXCT imaging. According to the progress of the study, the normal pathological examination showed that the lung was used. Now, in the middle of the MFXCT image, the pathological tissue of the SRCT imaging was detected. 3. Now that the temperature of the lung is normal, the SRCT is fine, the spatial decomposition energy is about 10 μ m, and the end of the lung is used to draw the image, and then confirm it. The pathology showed that the lungs were complicated, the lungs were complicated, the lungs and lungs were detected, the remodeling 2-D imaging was clearly defined, and the peripheral signs showed that there were multiple signs of lung disease. Pneumonia is a sign of lung disease. This is the sign of pneumonia. The radiation CT line is 3-D, the MFXC is fine, and the stereo line is 4. In the future, we will study and promote strategies to make sure that we have a lot of information, and what we have seen is a special situation in the form of remodeling. For example, in Pingcheng in 22 years, MFXCT has made sure that the method is correct and the analysis of the base is open. I don't know how to make a bear look like a bear.