Methodological development of quantitative tracer kinetic analysis in rodents using small animal PET.

利用转基因小鼠进行PET成像是发展神经系统疾病诊断成像技术的有利方法之一。利用动脉输入函数(AIF)定量分析放射性配基在活体器官中提供了精确的动力学，但在小鼠中测量AIF是困难的。在本研究中，对AIF的测量进行了动力学分析，并将其应用于淀粉样蛋白β斑块配体，以评估阿尔茨海默病模型小鼠的淀粉样蛋白β沉积。

PET imaging using transgenic mice is one of the advantageous methods for the development of the diagnostic imaging technology of neurological disease. Quantitative analysis of radioligand using arterial input function (AIF) provides precise kinetics in the living organs but the measurement of AIF is difficult in mice. In the present study the measurement of AIF was optimized for kinetic analysis and applied to amyloid β plaque ligand for the evaluation of amyloid β deposition in Alzheimer's disease model mice.